Mapeamento de fatores clínicos preditivos da neuropatia sensorial periférica induzida por oxaliplatina: revisão sistemática

Lívia Márcia Vidal Pires, Patrícia dos Santos Claro Fuly

Resumo

O objetivo deste estudo foi realizar um mapeamento dos fatores clínicos preditivos da Neuropatia Sensorial Periférica induzida pela Oxaliplatina. Para tanto, foi realizada uma revisão sistemática, elaborada a partir das recomendações da diretriz PRISMA. A estratégia PICO também foi utilizada para formular a questão de pesquisa e orientar a busca nas bases de dados: PubMed, Embase, Scopus, BVS/IBECS e CINAHL. Foram selecionadas 26 publicações para análise final e inclusão na revisão. As publicações foram classificadas quanto ao nível de evidência e grau de recomendação, de acordo com o sistema JBI. Na análise das publicações foram mapeados 15 fatores preditivos, com maior destaque para a dose cumulativa de Oxaliplatina utilizada. O reconhecimento dos fatores clínicos preditivos da Neuropatia Sensorial Periférica, independente da precocidade que possa ser feito, são importantes para a elaboração de estratégias mensuráveis no exercício do cuidado colaborativo e multidimensional.

Descritores: Toxicidade, Quimioterapia Combinada, Enfermagem Baseada em Evidências, Cuidados de Enfermagem, Neoplasias Colorretais.

 

Mapping of clinical factors predictive of oxaliplatin-induced peripheral sensory neuropathy: systematic review

Abstract: The aim of this study was to map the predictive clinical factors of Oxaliplatin-induced Peripheral Sensory Neuropathy. For that, a systematic review was carried out, based on the recommendations of the PRISMA guideline. The PICO strategy was also used to formulate the research question and guide the search in the databases: PubMed, Embase, Scopus, BVS/IBECS and CINAHL. 26 publications were selected for final analysis and inclusion in the review. The publications were classified according to the level of evidence and degree of recommendation, according to the JBI system. In the analysis of the publications, 15 predictive factors were mapped, with greater emphasis on the cumulative dose of Oxaliplatin used. The recognition of clinical predictive factors for Peripheral Sensory Neuropathy, regardless of the precocity that can be done, are important for the development of measurable strategies in the exercise of collaborative and multidimensional care.

Descriptors: Toxicity, Combined Chemotherapy, Evidence-Based Nursing, Nursing Care, Colorectal Neoplasms.

 

Mapeo de factores clínicos predictivos de neuropatía sensorial periférica inducida por oxaliplatino: revisión sistemática

Resumen: El objetivo de este estudio fue mapear los factores clínicos predictivos de la Neuropatía Sensorial periférica inducida por oxaliplatino. Para ello se realizó una revisión sistemática, con base en las recomendaciones de la guía PRISMA. También se utilizó la estrategia PICO para formular la pregunta de investigación y orientar la búsqueda en las bases de datos: PubMed, Embase, Scopus, BVS/IBECS y CINAHL. Se seleccionaron 26 publicaciones para su análisis final e inclusión en la revisión. Las publicaciones se clasificaron según el nivel de evidencia y grado de recomendación, según el sistema JBI. En el análisis de las publicaciones se mapearon 15 factores predictivos, con mayor énfasis en la dosis acumulada de Oxaliplatino utilizada. El reconocimiento de factores clínicos predictivos de la Neuropatía Sensorial Periférica, independientemente de la precocidad que se pueda realizar, es importante para el desarrollo de estrategias medibles en el ejercicio de la atención colaborativa y multidimensional.

Descriptores: Toxicidad, Quimioterapia Combinada, Enfermería Basada en Evidencias, Cuidado de Enfermera, Neoplasias Colorrectales.

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